Phosphoinositides in Subcellular Targeting and Enzyme Activation

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Curr Biol 18 : — Mol Biosyst 4 : — The PAR proteins: Fundamental players in animal cell polarization. Dev Cell 13 : — Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila.

J Cell Biol : — Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis.

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Adherens junctions: From molecules to morphogenesis. Nat Rev Mol Cell Biol 11 : — Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. Nat Rev Mol Cell Biol 9 : — A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions. PLoS One 2 : e Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.

J Mol Histol 40 : — Identification of genes required for cytoplasmic localization in early C. Cell 52 : — Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. Curr Biol 20 : — Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat Cell Biol 1 : 8 — Genome Biol 10 : Translation of the phosphoinositide code by PI effectors.

Phosphoinositides in Subcellular Targeting and Enzyme Activation

Nat Chem Biol 6 : — Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. Mechanism and dynamics of cadherin adhesion. Annu Rev Biomed Eng 8 : — Cell polarity and cancer—Cell and tissue polarity as a non-canonical tumor suppressor. Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 9 : 99 — Signal-dependent membrane targeting by pleckstrin homology PH domains. Biochem J : 1 — Oncogene 27 : — Restoring E-cadherin-mediated cell—cell adhesion increases PTEN protein level and stability in human breast carcinoma cells.

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Biochem Biophys Res Commun : — Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. Mechanical tugging force regulates the size of cell—cell junctions.

Proc Natl Acad Sci : — Biomechanical regulation of cell orientation and fate. Proc Natl Acad Sci 96 : — Pulsation and stabilization: contractile forces that underlie morphogenesis.


Dev Biol : — Pulsed contractions of an actin-myosin network drive apical constriction. Integration of contractile forces during tissue invagination. Phosphoinositides control epithelial development. Cell Cycle 6 : — Chapter 3: Acquisition of membrane polarity in epithelial tube formation patterns, signaling pathways, molecular mechanisms, and disease. Int Rev Cell Mol Biol : — PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc Cell : — Mutations in phosphoinositide metabolizing enzymes and human disease.

Physiology Bethesda 24 : 8 — The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. Nature : 93 — Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. Exp Cell Res : — PAR proteins and the cytoskeleton: A marriage of equals. Curr Opin Cell Biol 18 : 86 — EMBO J 20 : — Dev Cell 14 : — Remodeling epithelial cell organization: Transitions between front—rear and apical—basal polarity.

Opinion: Building epithelial architecture: Insights from three-dimensional culture models.

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Nat Rev Mol Cell Biol 3 : — Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol : — Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem 79 : — Mol Cell 32 : — Lipid binding to the tail domain of vinculin: Specificity and the role of the N and C termini.

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New aspects of integrin signaling in cancer. Semin Cancer Biol 10 : — The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front—rear polarity. Curr Biol 17 : — Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Regulated and polarized PtdIns 3,4,5 P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

Curr Biol 16 : — Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos. Sci Signal 2 : ra Genes Cells 14 : — Science : — Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. Epithelial morphogenesis in embryos: asymmetries, motors and brakes. Trends Genet 24 : — Vesicle transport, cilium formation, and membrane specialization: The origins of a sensory organelle.

Annexin 2 is a phosphatidylinositol 4,5 -bisphosphate binding protein recruited to actin assembly sites at cellular membranes. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. Cdcdependent modulation of tight junctions and membrane protein traffic in polarized Madin—Darby canine kidney cells.

Mol Biol Cell 12 : — Making tubes: Step by step. Regulation of the actin cytoskeleton—plasma membrane interplay by phosphoinositides. Physiol Rev 90 : — Apical constriction: A cell shape change that can drive morphogenesis. Dev Biol : 5 — Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation.

Mol Biol Cell 20 : — Cell adhesion receptors in mechanotransduction. Curr Opin Cell Biol 20 : — Intercellular junctions: Actin the PARt. Curr Biol 18 : R — Sequential activation of apical and basolateral contractility drives ascidian endoderm invagination. Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell—cell contacts. Mol Biol Cell 16 : — Cell : 63 — Dev Cell 19 : — Mol Cell Biol 18 : — Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens.

Nat Cell Biol 12 : — Pulsed forces timed by a ratchet-like mechanism drive directed tissue movement during dorsal closure. Cell polarity in eggs and epithelia: Parallels and diversity. Neuronal polarity.

Targeting and localized signalling by small GTPases. Biol Cell 99 : 1 — Targeted disruption of the mouse Rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol 23 : — Blood : — Non-muscle myosin II takes centre stage in cell adhesion and migration.

Phosphoinositides in Cell Architecture

Nat Rev Mol Cell Biol 10 : — Apical junctional complexes and cell polarity. Kidney Int 72 : — Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance. Nonmuscle myosin II isoform and domain specificity during early mouse development. Of relevance to this idea is the observation that host sphingolipid synthesis, a process known to be under the control of PI 4-kinases, is known to be greatly upregulated during HCV infection [,].

Consistent with this proposal, a number of reports have demonstrated HCV-induced alterations to pro-oncogenic signalling pathways [—]. It remains to be established though, if elevated PI4P at the virally-induced compartment constitutes a signalling competent pool capable of supplying substrate to upstream phosphoinositide kinases and phospholipases at the plasma membrane and endosomes. Another proviso is that alterations to signalling and trafficking could be accounted for by the interactions of viral proteins with multiple host proteins.