Dietary Magnesium: New Research
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In a study conducted on a small number of osteoporotic postmenopausal women, biochemical features of suppressed bone turnover were seen in women who consumed oral magnesium citrate for 30 days. Figure 3. Commonly encountered features of magnesium deficiency in the clinical setting. Consuming the RDA of magnesium may be more effective in preventing bone thinning than vitamin D, as magnesium potentiates vitamin D activities, possibly by increasing its absorption and endogenous activation.
Magnesium has been found to be a contributing factor in patients with established osteoporosis with vitamin D deficiency and blunted PTH level. A study in mice showed that magnesium deficiency during pregnancy influences both maternal and fetal fatty acid metabolism and adversely affects fetal growth and survival, emphasizing the importance of adequate maternal magnesium status for better pregnancy outcome. Magnesium is an essential cofactor for vitamin D synthesis, and activated vitamin D, in turn, can increase intestinal absorption of magnesium and, therefore, can form a feed-forward loop to maintain its homeostasis.
With regard to the musculoskeletal system, future study may explore the synergistic effect of vitamin D and magnesium levels along with osteopathic manipulative treatment on performance. The roles and regulation of magnesium in health and diseases are a rapidly evolving area. Studies have shown that magnesium supplementation can increase the effectiveness of vitamin D activity; therefore, further controlled studies should determine the dose of magnesium required for a particular clinical situation for reducing vitamin D—associated disorders.
Magnesium homeostasis is maintained by the delicate interactions of the intestine, bone, and kidneys. Magnesium is an essential cofactor for vitamin D synthesis and activation and, in turn, can increase intestinal absorption of magnesium and establish a feed-forward loop to maintain its homeostasis.
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Dysregulation in either of these nutrients can be associated with various disorders, including skeletal deformities, cardiovascular disorders, and metabolic syndrome. A better understanding of how magnesium supplementation might reduce complications related to vitamin D deficiency would help improve patient care.
Magnesium and Human Health: Perspectives and Research Directions
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